Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction

Beilstein Journal of Organic Chemistry

卷:10

Xiaoan Wen¹  Xiantao Lei¹  Hong-Jin Du¹  Hongbin Sun¹  Qing-Long Xu¹  Chun-Huan Jiang¹  Le Zhen¹ 

[1] State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China;

关键词: catalysis;    C–H activation;    hydride-shift;    Lewis acid;    redox reaction;   

DOI  :  10.3762/bjoc.10.306

来源: DOAJ

【 摘 要 】

Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolcular [1,5]-hydride shift/isomerization reaction has been realized, using the inherent reducing power of 3-pyrrolines. A series of N-arylpyrrole containing amines are obtained in high yields.

【 授权许可】

Unknown