Information feedback of 18F-FDG PET/CT computer imaging combined with tumor markers on recurrence and metastasis of non-small cell lung cancer

Journal of Infection and Public Health

卷:13

Yindong Mu¹  Lei Yan¹  Chunhui Ren²  Jinqiu Gui³  Hua Feng⁴  Haifeng Liu⁵  Zhifang Lang⁶  Jun Liang⁷ 

[1] Department of Histology and Embryology, Mudanjiang Medical University, Mudanjiang 157011, China;

[2] Department of Image, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang 157011, China;

[3] Department of Pathogenic Microbiology, Mudanjiang Medical University, Mudanjiang 157011, China;

[4] Department of Pathophysiology, Mudanjiang Medical University, No. 3 Tongxiang Road, Mudanjiang, Heilongjiang, China;

[5] Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang 157011, China;

[6] Medical Functional Laboratory, Mudanjiang Medical University, Mudanjiang 157011, China;

[7] Stem Cell Institute, Mudanjiang Medical University, Mudanjiang 157011, China;

关键词: 18F-FDG PET/CT imaging;    Emission computer;    Tumor marker;    Non-small cell lung cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

To investigate the diagnostic value or information feedback of tumor markers combined with 18F-FDG PET/CT computer imaging on recurrence and metastasis of non-small cell lung cancer (NSCLC). Methods: From January 2013 to December 2017, 95 NSCLC patients undergoing systemic 18F-FDG PET/CT computer imaging examination at the PET/CT computer imaging center of Mudanjiang Medical University had been enrolled. Typically, the interval between the completion of treatment and PET/CT computer imaging examination should be at least three months. Besides, all patients had undergone serum CEA monitoring before and after 18F-FDG PET/CT computer imaging, and 70 of them had received CYFRA21-1 test at the same time. Tumor markers were examined with PET/CT at intervals of less than one week, and all the feedback results were compared with clinical follow-up results or final pathology. Additionally, all the enrolled patients were followed up for 6–12 months. Results: The sensitivity, accuracy, specificity, positive predictive value and negative predictive value of 18F-FDGPET/CT information feedback in evaluating recurrence or metastasis after NSCLC treatment were superior to those of common tumor markers, and the differences were statistically significant (P < 0.05). Those of 18F-FDG PET/CT computer imaging combined with tumor marker examination for the recurrence and/or metastasis after NSCLC treatment were remarkably higher than those of either individual examination, and the accuracy difference of information feedback had significant statistical significance (P < 0.05). Clearly, the diagnosis using tumor markers was correlated with that by 18F-FDG PET/CT imaging, and the correlation coefficient was r = 0.63. Moreover, serum CEA was grouped at different levels, and the positive rate and accuracy of 18F-FDG PET/CT computer imaging diagnosis were increased with the increase in CEA level. 8 patients had received 18F-FDG PET/CT dual-phase examination, among them, 4 were diagnosed with recurrence or metastasis after MSCLC treatment, and all of them had been detected.

【 授权许可】

Unknown