TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]

Journal of Lipid Research

卷:55

Tiffany A. Melhuish¹  Paolo Parini²  Zhao-Yan Jiang³  David Wotton³  Mats Eriksson⁴  Camilla Pramfalk⁵ 

[1] Molecular Nutrition Unit, Department of Biosciences and Nutrition, Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden;

[2] and;

[3] Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, VA;

[4] Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;

[5] Division of Clinical Chemistry, Department of Laboratory Medicine, and Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden;

关键词: hepatocyte nuclear factor 1α and 4α;    liver;    human;    triglyceride;   

DOI  :  

来源: DOAJ

【 摘 要 】

Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2. Tgif1 could also block the induction of the SOAT2 promoter activity by hepatocyte nuclear factor 1α and 4α. Women have ∼30% higher hepatic TGIF1 mRNA compared with men. Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism.

【 授权许可】

Unknown