A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

Pharmaceutics

卷:10

AndreaLi-Ann Wong¹  Ian Wee¹  BoonCher Goh¹  Nicholas Syn¹  WeiPeng Yong¹  Lingzhi Wang¹  AlanPrem Kumar¹  Gautam Sethi²  PeiShi Ong³  PaulChi-Lui Ho³  EeQin Ying Mitchell³  Xiaoqiang Xiang⁴ 

[1] Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore;

[2] Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore;

[3] Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore;

[4] School of Pharmacy, Fudan University, Shanghai 201203, China;

关键词: LC-MS/MS;    rapid;    quantification;    oncology drugs;   

DOI  :  10.3390/pharmaceutics10040221

来源: DOAJ

【 摘 要 】

In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation.

【 授权许可】

Unknown