ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS

Научно-практическая ревматология

卷:52

E. G. Filatova¹  E. F. Turovskaya²  L. I. Alekseeva³  Sh. F. Erdes³  E. S. Filatova³ 

[1] I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia;

[2] V.A. Nasonova Research Institute of Rheumatology, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia;

[3] V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia;

关键词: rheumatoid arthritis;    knee osteoarthritis;    neuropathic pain component;    chronic pain syndrome;   

DOI  :  10.14412/1995-4484-2014-631-635

来源: DOAJ

【 摘 要 】

Objective: to reveal neurogenic mechanisms in the pathogenesis of chronic pain syndrome in rheumatoid arthritis (RA) and knee osteoarthritis (OA) in order to develop individualized pharmacotherapy.Subjects and methods. One hundred and eighty-three patients with RA and 80 with knee OA were examined. By using the neuropathic pain diagnostic questionnaire (DN4), all the patients were divided into 2 groups with and without a neuropathic pain component (NPC).Results. NPC was found in 43% of the patients with RA and it was connected with involvement of the peripheral somatosensory system. In RA, NPC was common in older patients with longer disease duration, higher X-ray stage, and severe functional insufficiency. 30% of patients with knee OA also had NPC, however the signs of nervous system involvement were absent. In OA, NPC was associated with hyperalgesia, higher pain intensity, more marked joint dysfunction on the WOMAC, and anxiety.Discussion. This investigation revealed a mixed pattern of chronic pain syndrome in patients with RA and knee OA; some patients were found to have a NPC in the presence of predominantly a nociceptive component

【 授权许可】

Unknown