Vesicles from Amphiphilic Dumbbells and Janus Dendrimers: Bioinspired Self-Assembled Structures for Biomedical Applications

Polymers

卷:9

Soraya Taabache¹  Annabelle Bertin¹ 

[1] Federal Institute for Materials Research and Testing (BAM), Department 6.0, D-12205 Berlin, Germany;

关键词: Janus dendrimers;    amphiphilic dumbbells;    self-assembled structures;    vesicles;    dendrimersomes;    drug delivery systems;    theranostics;    artificial cells;    lectin recognition;    self-sorting;   

DOI  :  10.3390/polym9070280

来源: DOAJ

【 摘 要 】

The current review focuses on vesicles obtained from the self-assembly of two types of dendritic macromolecules, namely amphiphilic Janus dendrimers (forming dendrimersomes) and amphiphilic dumbbells. In the first part, we will present some synthetic strategies and the various building blocks that can be used to obtain dendritic-based macromolecules, thereby showing their structural versatility. We put our focus on amphiphilic Janus dendrimers and amphiphilic dumbbells that form vesicles in water but we also encompass vesicles formed thereof in organic solvents. The second part of this review deals with the production methods of these vesicles at the nanoscale but also at the microscale. Furthermore, the influence of various parameters (intrinsic to the amphiphilic JD and extrinsic—from the environment) on the type of vesicle formed will be discussed. In the third part, we will review the numerous biomedical applications of these vesicles of nano- or micron-size.

【 授权许可】

Unknown