Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material

Polymers

卷:14

Yasin Karacelebi¹  Eray Altan²  Elif Saatcioglu²  Oguzhan Gunduz²  Songul Ulag³  Ali Sahin⁴  Burak Aksu⁵  Cosmin Iulian Codrea⁶  Anton Ficai⁶  Alexa-Maria Croitoru⁶  Denisa Ficai⁷ 

[1] Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul 34722, Turkey;

[2] Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey;

[3] Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Department of Metallurgical and Materials Engineering, Institute of Pure and Applied Sciences, Marmara University, Istanbul 34722, Turkey;

[4] Department of Biochemistry, Faculty of Medicine, Marmara University, Istanbul 34722, Turkey;

[5] Department of Medical Microbiology, Faculty of Medicine, Marmara University, Istanbul 34722, Turkey;

[6] Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Gh Polizu Street, 060042 Bucharest, Romania;

[7] National Centre for Micro and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania;

关键词: electrospinning;    polylactic acid;    juglone;    skin tissue engineering;    wound dressing;   

DOI  :  10.3390/polym14101971

来源: DOAJ

【 摘 要 】

Juglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods.

【 授权许可】

Unknown