Ferroptosis Signaling and Regulators in Atherosclerosis

Frontiers in Cell and Developmental Biology

卷:9

Liming Yang¹  Hong Li²  Yajie Zhao²  Ting Ye²  Yuqin Wang²  Yanna Shen³ 

[1] Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, China;

[2] Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China;

[3] School of Medical Laboratory, Tianjin Medical University, Tianjin, China;

关键词: ferroptosis;    atherosclerosis;    Nrf2;    p53;    Hippo;   

DOI  :  10.3389/fcell.2021.809457

来源: DOAJ

【 摘 要 】

Atherosclerosis (AS) is a major cause of cardiovascular diseases such as coronary heart disease, heart failure and stroke. Abnormal lipid metabolism, oxidative stress and inflammation are the main features of AS. Ferroptosis is an iron-driven programmed cell death characterized by lipid peroxidation, which have been proved to participate in the development and progression of AS by different signal pathways. NRF2-Keap1 pathway decreases ferroptosis associated with AS by maintaining cellular iron homeostasis, increasing the production glutathione, GPX4 and NADPH. The p53 plays different roles in ferroptosis at different stages of AS in a transcription-dependent and transcription- independent manner. The Hippo pathway is involved in progression of AS, which has been proved the activation of ferroptosis. Other transcription factors, such as ATF3, ATF4, STAT3, also involved in the occurrence of ferroptosis and AS. Certain proteins or enzymes also have a regulatory role in AS and ferroptosis. In this paper, we review the mechanism of ferroptosis and its important role in AS in an attempt to find a new relationship between ferroptosis and AS and provide new ideas for the future treatment of AS.

【 授权许可】

Unknown