Synthesis and In Vitro (Anticancer) Evaluation of η6-Arene Ruthenium Complexes Bearing Stannyl Ligands

Inorganics

卷:5

Haleden Chiririwa¹  Siyabonga Ngubane²  Paul J. Dyson³  Tina Riedel³  Judith Baumgartner⁴  Catherine Russon⁵  Olivier Renier⁵  Kunsulu Nurekeyeva⁵  Simba Dyson⁵  Connor Deacon-Price⁵  Joannes E. B. Peters⁵  Burgert Blom⁵ 

[1] Biosorption and Water Research Laboratory Department of Chemistry, Vaal University of Technology, Private Bag X021, Andries Potgieter Blvd, Vanderbijlpark 1911, South Africa;

[2] Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa;

[3] Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH­1015 Lausanne, Switzerland;

[4] Institut für Anorganische Chemie, Technische Universität Graz, Stremayrgasse 9, A-8010 Graz, Austria;

[5] Maastricht Science Programme, Faculty of Humanities and Science, Maastricht University, Kapoenstraat 2, P.O. Box 616, 6200 MD Maastricht, The Netherlands;

关键词: bioorganometallic chemistry;    metal-based drugs;    phosphorus ligands;    ruthenium;    half-sandwich complexes;    tin dichloride insertion;   

DOI  :  10.3390/inorganics5030044

来源: DOAJ

【 摘 要 】

Treatment of the known half-sandwich complexes of the type [(η6-C6H6)RuCl2(P(OR)3)] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1–C3): [(η6-C6H6)RuCl(SnCl3)(P(OMe)3)] (C1), [(η6-C6H6)RuCl(SnCl3)(P(OPh)3)] (C2) and the bis-stannyl complex [(η6-C6H6)Ru(SnCl3)2(P(OMe)3)] (C3) by facile insertion of SnCl2 into the Ru–Cl bonds. Treatment of the known complexes [(η6-C6H6)RuCl(SnCl3)(PPh3)] and [(η6-C6H6)RuCl2(PPh3)] with 4-dimethylaminopyridine (DAMP) and ammonium tetrafluoroborate afforded the complex salts: [(η6-C6H6)Ru(SnCl3)(PPh3)(DAMP)]+BF4− (C4) and [(η6-C6H6)RuCl(PPh3)(DAMP)]+BF4− (C5) respectively. Complexes C1–C5 have been fully characterized by spectroscopic means (IR, UV–vis, multinuclear NMR, ESI–MS) and their thermal behaviour elucidated by thermal gravimetric analysis (TGA). Structural characterization by single crystal X-ray crystallography of the novel complex C2 and [(η6-C6H6)RuCl2(P(OPh)3)], the latter having escaped elucidation by this method, is also reported. Finally, the cytotoxicity of the complexes was determined on the A2780 (human ovarian cancer), A2780cisR (human ovarian cis-platin-resistant cancer), and the HEK293 (human embryonic kidney) cell lines and discussed, and an attempt is made to elucidate the effect of the stannyl ligand on cytotoxicity.

【 授权许可】

Unknown