Central hemodynamics in elderly patients with arterial hypertension treated with perindopril A/indapamide (Noliprel A/forte) and lowintensity laser therapy

Кардиоваскулярная терапия и профилактика

卷:10

A. A. Perfiliev¹  V. V. Shadrin¹  G. G. Efremushkin²  T. V. Filippova²  Yu. A. Melnikova² 

[1] ;

[2] Altay State Medical University;

关键词: arterial hypertension;    central hemodynamics;    elderly age;    low-intensity laser therapy;    noliprel a/forte;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim. To compare the effects of combination therapy with Noliprel A/forte (perindopril/indapamide) and lowintensity laser therapy (LILT) on central hemodynamics in elderly patients with arterial hypertension (AH). Material and methods. In total, 160 AH patients, aged 60-96 years, were examined. All participants were randomised into 4 groups: Group I (n=25) receiving Noliprel A/forte; Group II (n=54) receiving red-spectrum LILT on skin Zakharyin-Ged zones, plus pharmaceutical therapy (excluding noliprel); Group III (n=27) receiving Noliprel A/forte and LILT; and Group IV (n=54), the comparison group, receiving standard antihypertensive therapy only (excluding Noliprel A/forte and/or LILT). At baseline and in the end of the study, Doppler ultrasound parameters were assessed. Results. At baseline, AH patients demonstrated relatively normal systolic myocardial function combined with diastolic left and right ventricular (LV, RV) dysfunction and increased ventricular transverse sizes. By the end of the study, Group I demonstrated reverse remodelling of all cardiac chambers. The combination of Noliprel A/forte and LILT had additive beneficial effects on morphological and functional components of intracardiac hemodynamics, with LV and RF systolic function improvement and even more pronounced regression of LV and RF diastolic dysfunction. The beneficial impact of noliprel was maximal in patients aged over 80 years. Conclusion. The combination of noliprel and LILT demonstrated additive beneficial effects and increased treatment effectiveness independently of AH variant, intracardiac hemodynamic specifics, and age.

【 授权许可】

Unknown