Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats

Molecules

卷:27

Xinzhang Chen¹  Di Qiu¹  Meilun Shen¹  Li Gao¹  Zhiheng Zhang¹  Xiangying Ma¹  Siyao Li¹ 

[1] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China;

关键词: ketamine;    developing rats;    livers;    NLRP3/Caspase-1;   

DOI  :  10.3390/molecules27092931

来源: DOAJ

【 摘 要 】

Ketamine is an anesthetic drug that is widely used in human and veterinary medicine. In the developmental stage, long-term exposure to ketamine may cause serious side effects. MCC950 and VX765 play protective roles in many disease models by regulating the NLRP3/Caspase-1 pathway. This study aims to explore the potential protective effect of MCC950 and VX765 on ketamine-induced liver injury in neonatal rats and clarify its underlying mechanism. After administration of MCC950 and VX765 in a ketamine-induced liver injury rat model, liver function and inflammatory factors were determined, and immunohistochemistry and western blotting were performed. We found that ketamine caused liver injury in 7-day-old SD rats, decreased liver function indexes, and increased inflammation. MCC950 and VX765 effectively alleviated liver damage and inflammation, and downregulated the expression of proteins such as NLRP3, Caspase-1, and GSDMD-N. In summary, these results indicated that MCC950 and VX765 could have potential protective effects on ketamine-induced liver injury through inhibiting the NLRP3/Caspase-1 pathway.

【 授权许可】

Unknown