Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports

Journal of Medical Case Reports

Yves Castier¹  Pierre Mordant¹  Raphael Borie²  Cendrine Godet³  Samer Najem³  Vincent Bunel³  Sixtine Decaux³  Jonathan Messika³  Tiphaine Goletto³  Chahine Medraoui³  Gaëlle Weisenburger³  Hervé Mal⁴  Marie Pierre Debray⁵  Brice Lortat-Jacob⁶  Lila Bouadma⁷ 

[1] Service de Chirurgie Vasculaire, Thoracique et Transplantation Pulmonaire, Hôpital Bichat, Paris, France;Service de Pneumologie A, Hôpital Bichat, Paris, France;Service de Pneumologie B, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018, Paris, France;Inserm UMR1152, Université Paris7 Denis Diderot, 75018, Paris, France;Service de Pneumologie B, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018, Paris, France;Inserm UMR1152, Université Paris7 Denis Diderot, 75018, Paris, France;Service de Pneumologie B et Transplantation Pulmonaire, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France;Service de Radiologie, Hôpital Bichat, Paris, France;Service de Réanimation Chirurgicale, Hôpital Bichat, Paris, France;Service de Réanimation Médicale et Infectieuse, Hôpital Bichat, Paris, France;

关键词: Lung fibrosis;    Idiopathic pulmonary fibrosis;    Hypoxemia;    Lung infection;    Lung transplantation;   

DOI  :  10.1186/s13256-021-03191-9

来源: Springer

【 摘 要 】

BackgroundIn patients receiving single lung transplantation for idiopathic pulmonary fibrosis, worsening of fibrosis of the native lung is usually progressive over time, with no significant effects on gas exchange.Case presentationHere, we describe the cases of two Caucasian male recipients of single lung transplants for idiopathic pulmonary fibrosis, 65 and 62 years of age, who exhibited acute worsening of lung fibrosis after an episode of serious viral infection (cytomegalovirus primo-infection in one case and COVID-19 in the other). In both cases, along with opacification of the native lung over several days, the patients presented acute respiratory failure that required the use of high-flow nasal oxygen therapy. Eventually, hypoxemic respiratory failure resolved, but with rapid progression of fibrosis of the native lung.ConclusionWe conclude that acute worsening of fibrosis on the native lung secondary to a severe viral infection should be added to the list of potential complications developing on the native lung after single lung transplantation for idiopathic pulmonary fibrosis.

【 授权许可】

CC BY