Progress on the roles of MEF2C in neuropsychiatric diseases

Molecular Brain

Yongxiang Zhao¹  Zhikun Zhang² 

[1] National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, 530021, Nanning, Guangxi, China;National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, 530021, Nanning, Guangxi, China;Department of Mental Health, The Second Affiliated Hospital of Guangxi Medical University, 530007, Nanning, Guangxi, China;

关键词: MEF2C;    Transcription factor;    Synapse;    Neurodevelopment;    Neuropsychiatric disease;   

DOI  :  10.1186/s13041-021-00892-6

来源: Springer

【 摘 要 】

Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer’s disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases.

【 授权许可】

CC BY