Success of small-dose fractionated sodium thiosulfate in the treatment of calciphylaxis in a peritoneal dialysis patient

BMC Nephrology

Deyu Xu¹  Yuan Lu¹  Lei Shen¹  Ling Zhou¹ 

[1] Department of Nephrology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, 215008, Suzhou, Jiangsu, China;

关键词: Calciphylaxis;    Sodium thiosulfate;    Peritoneal dialysis;    Vascular calcification;   

DOI  :  10.1186/s12882-021-02648-9

来源: Springer

【 摘 要 】

BackgroundCalciphylaxis, or calcific uremic arteriolopathy (CUA), is a rare, fatal disorder of microvascular calcification and thrombosis that typically affects patients with end-stage renal disease (ESRD) receiving long-term dialysis. Fewer reports describe calciphylaxis in peritoneal dialysis patients than hemodialysis patients as per a literature review. To date, there are no clear guidelines for CUA diagnosis and treatment. While sodium thiosulfate (STS) has been increasingly used for treatment in recent years, there have also been reports of severe side effects. There is no uniform standard for its usage and dosage, especially for peritoneal dialysis patients.Case presentationWe present a case of a 40-year-old Chinese male patient with ESRD on peritoneal dialysis who developed calciphylaxis with severe painful cutaneous ulcers on the fingers and toes that were managed successfully for 6 months with comprehensive treatment composed mainly of small-dose fractionated sodium thiosulfate.ConclusionsOur experience suggests that the treatment of calciphylaxis requires timely and multi-angle intervention. Treatment with small-dose fractionated sodium thiosulfate has proven effective and tolerated in this patient.

【 授权许可】

CC BY