Associations of a healthy lifestyle score from childhood to adulthood with subclinical kidney damage in midlife: a population-based cohort study

BMC Nephrology

Ye He¹  Alison J. Venn¹  Conghui Liu¹  Jing Tian¹  Terence Dwyer²  Matthew D. Jose³ 

[1] Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, 7000, Hobart, Tasmania, Australia;Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, 7000, Hobart, Tasmania, Australia;The George Institute for Global Health, University of Oxford, Oxford, UK;School of Medicine, University of Tasmania, Hobart, Tasmania, Australia;

关键词: Healthy lifestyle;    Longitudinal studies;    Chronic kidney disease;    Child;    Adult;   

DOI  :  10.1186/s12882-021-02627-0

来源: Springer

【 摘 要 】

BackgroundThe relationships of healthy lifestyle scores (HLS) of various kinds in adulthood with the risk of chronic kidney disease (CKD) have been reported, but little is known about the association of childhood lifestyle with later life CKD. This study examined the relationship of HLS from childhood to adulthood with subclinical kidney damage (SKD) in midlife, a surrogate measure for CKD.MethodsData were collected in an Australian population-based cohort study with 33 years follow-up. 750 participants with lifestyle information collected in childhood (ages 10–15 years) and midlife (ages 40–50 years), and measures of kidney function in midlife were included. The HLS was generated from the sum scores of five lifestyle factors (body mass index, smoking, alcohol consumption, physical activity, and diet). Each factor was scored as poor (0 point), intermediate (1 point), or ideal (2 points). Log-binomial regression was used to investigate the relationship of HLS in childhood and from childhood to adulthood with SKD defined as either 1) estimated glomerular filtration rate (eGFR) 30–60 mL/min/1.73m2 or 2) eGFR> 60 mL/min/1.73m2 with urine albumin-creatinine ratio ≥ 2.5 mg/mmol (males) or 3.5 mg/mmol (females), adjusting for socio-demographic factors and the duration of follow-up.ResultsThe average HLS was 6.6 in childhood and 6.5 in midlife, and the prevalence of SKD was 4.9% (n = 36). Neither HLS in childhood nor HLS from childhood to adulthood were significantly associated with the risk of SKD in midlife.ConclusionsA HLS from childhood to adulthood did not predict SKD in this middle-aged, population-based Australian cohort.

【 授权许可】

CC BY