Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China

Virology Journal

Yuan Song¹  Xiaofei Wei¹  Lijun Zhao¹  Xiangpeng Wang¹  Mingyong Wang¹  Ruili Sun¹  Guanyu Wang² 

[1] Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China;Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China;Department of Clinical Laboratory, Xinxiang Central Hospital, 453000, Xinxiang, Henan, China;

关键词: Human papillomavirus;    Genotype;    Cervical cancer;    Vaccine;   

DOI  :  10.1186/s12985-021-01732-8

来源: Springer

【 摘 要 】

BackgroundHuman papillomavirus (HPV) infection can cause cervical and other cancers, including vulva, vagina, penis, anus, or oropharynx. However, in China's northern Henan Province, data on the prevalence and genotype distribution of HPV among women attending gynecology clinics is limited. This study aimed to investigate the current prevalence and genotype distribution of HPV among women attending gynecology clinics in northern Henan Province.MethodsThis study included 15,616 women aged 16–81 years old who visited the Xinxiang central hospital's gynecology department between January 2018 and December 2019. HPV DNA was detected by a conventional PCR method followed by HPV type-specific hybridization, which was designed to detect 17 high-risk HPV (HR-HPV) genotypes and 20 low-risk HPV (LR-HPV) genotypes. HPV prevalence and corresponding 95% confidence intervals (95% CI) were calculated using SPSS 18.0.ResultsThe overall HPV prevalence was 19.7% among women in northern Henan Province. Single, double, and multiple HPV infections accounted for 13.7%, 4.3%, and 1.8% of the total cases. Most infections were caused by HR-HPV (71.8%), and single genotype HPV infection (13.7%) was the most common pattern. The most common HR-HPV genotype was HPV16 (4.3%), followed by HPV52 (3.5%) and HPV58 (2.0%). The most common LR-HPV genotype was HPV6 (1.4%), followed by HPV61 (1.1%) and HPV81 (1.1%).ConclusionsHPV infection is high among women attending gynecology clinics in northern Henan Province. The highest prevalence was found in women less than 20 years old. In northern Henan Province, the 9-valent HPV vaccine is strongly recommended for regular immunization.

【 授权许可】

CC BY