Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort

Journal of Cardiovascular Magnetic Resonance

Jason Hicks¹  Jennifer Vena²  Tiago Teixeira³  Eric E. Smith⁴  Matthias G. Friedrich⁵  Philip Awadalla⁶  Catherine Gebhard⁷  Philippe Broet⁸  Judy M. Luu⁹  Eric Larose^1,10  Douglas S. Lee^1,11  Dipika Desai^1,12  Chinthanie Ramasundarahettige^1,13  Karleen Schulze^1,13  Sonia S. Anand^1,14  Koon K. Teo^1,14  Jean-Claude Tardif^1,15  Francois Marcotte^1,15  Trevor Dummer^1,16  Alan Moody^1,17 

[1] Atlantic PATH, Dalhousie University, P.O. Box 15000, 1494 Carlton Street, B3H 4R2, Halifax, NS, Canada;Cancer Research and Analytics, Cancer Control Alberta, Alberta Health Services, Suite 1500 Sun Life Place, 10123 99th Street NW, T5J 3H1, Edmonton, AB, Canada;Cardiology Department, Entre Douro e Vouga Hospital Centre, Santa Maria Feira, Portugal;Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, T2N 4N1, Calgary, AB, Canada;Department of Medicine and Diagnostic Radiology, McGill University, 1001 Decarie Boulevard, H4A 3J1, Montreal, QC, Canada;Department of Molecular Genetics, Ontario Institute for Cancer Research, University of Toronto, 661 University Avenue Suite 510, M5G 0A3, Toronto, ON, Canada;Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland;Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland;Department of Preventive and Social Medicine, École de Santé Publique, Université de Montréal, 3175 Chemin de la Cote-Sainte-Catherine, H3T 1C5, Montreal, QC, Canada;Research Centre, CHU Sainte Justine, 3175 Chemin de la Cote-Sainte-Catherine, H3T 1C5, Montreal, QC, Canada;Division of Cardiology, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada;Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval, 2725 chemin Sainte-Foy, G1V 4G5, Quebec, Canada;Institute for Clinical Evaluative Sciences, Toronto, ON, Canada;Peter Munk Cardiac Centre University Health Network University of Toronto, Toronto, ON, Canada;Population Health Research Institute, Hamilton Health Sciences, McMaster University, 237 Barton St East, L8L 2X2, Hamilton, ON, Canada;Population Health Research Institute, Hamilton Health Sciences, McMaster University, 237 Barton St East, L8L 2X2, Hamilton, ON, Canada;Department of Medicine, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada;Population Health Research Institute, Hamilton Health Sciences, McMaster University, 237 Barton St East, L8L 2X2, Hamilton, ON, Canada;Department of Medicine, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada;Department of Health Evidence and Impact, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada;Research Centre, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, H1T 1C8, Montreal, QC, Canada;School of Population and Public Health, Cancer Control Research, BC Cancer, University of British Columbia, 675 W 10th Avenue, V5Z 1L3, Vancouver, BC, Canada;Sunnybrook Health Science Centre, Toronto, ON, Canada;

关键词: Sex;    Age;    Cardiovascular magnetic resonance;    Reference;    Normal;   

DOI  :  10.1186/s12968-021-00819-z

来源: Springer

【 摘 要 】

BackgroundDespite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters.Methods and resultsParticipants (n = 3206, 65% females; age 55.2 ± 8.4 years for females and 55.1 ± 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001).ConclusionUsing anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date.Clinical trial registrationClinicalTrials.gov, NCT02220582. Registered 20 August 2014—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02220582.

【 授权许可】

CC BY