Characteristics and clinical significance of lipid metabolism in patients with gastrointestinal stromal tumor

Lipids in Health and Disease

Jun Hu¹  Xiaoling Liu¹  Bende Liu² 

[1] Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Since and Technology, 39Yanhu Avenue, Hongshan District, 430022, Wuhan, Hubei, China;Department of Union Jiangnan Hospital Huazhong University of Science and Technology, 1 Wenhua Avenue, Jiangxia District, 430022, Wuhan, Hubei, China;Department of Cardiovascular system Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, 430022, Wuhan, Hubei, China;

关键词: Gastrointestinal stromal tumor;    Lipid metabolism;    Clinical pathology;    GIST;    Lipid;    Risk stratification;   

DOI  :  10.1186/s12944-021-01613-7

来源: Springer

【 摘 要 】

BackgroundTo investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumors (GISTs).MethodsThe clinical and pathological data of 694 GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. Blood lipid levels in patients with varying degrees of risk were compared.ResultsThe findings showed that LDL-C, HDL-C, and CHOL increased significantly in women, and CD34 positive. In patients with tumors size less than 5 cm in diameter, TG, HDL-C, and CHOL were significantly higher. TG levels were significantly higher in DOG-1 (a marker and has a high specificity and sensitivity in the diagnosis of GIST) positive patients than in DOG-1 negative patients (P < 0.05). S-100 positive patients had lower HDL-C levels than S-100 negative patients (P < 0.05). Lipids indexes were found to be correlated with GIST risk stratification and tumor site (P < 0.05). TG/HDL-C was were significantly different among patients with GIST in different locations (P < 0.05).ConclusionThe clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. To a certain extent, information about level of blood lipids can be helpful for distinguishing benign and malignant GIST.

【 授权许可】

CC BY