Subacute thyroiditis during early pregnancy: a case report and literature review

BMC Pregnancy and Childbirth

Chao-Fang Bai¹  Xing-Qian Geng¹  Ying Yang¹  Ke Yang²  Melvin R Hayden³  Guang-Hui Shen⁴ 

[1] Department of Endocrinology, Second People’s Hospital of Yunnan Province, Affiliated Hospital of Yunnan University, 650000, Kunming, Yunnan Province, China;Department of Vascular and Cardiology, Ruijin Hospital, Shanghai Jiaotong University of Medicine, 201102, Shanghai, China;Departments of Internal Medicine , Endocrinology Diabetes and Metabolism , Diabetes and Cardiovascular Disease Center, University of Missouri School of Medicine, Columbia, MO, USA;Institute of Pediatrics of Children’s Hospital of Fudan University, 201102, Shanghai, China;

关键词: Subacute Thyroiditis;    Pregnancy;    Hormones;    Hyperthyroidism;    Case report;   

DOI  :  10.1186/s12884-021-04368-2

来源: Springer

【 摘 要 】

BackgroundSubacute thyroiditis (SAT) is rarely diagnosed in pregnant women, and only 7 cases have been reported to date. Thyroid dysfunction, especially hyperthyroidism, during pregnancy has been associated with both maternal and neonatal complications. Thus, the early diagnosis and treatment of SAT during pregnancy may be beneficial. We present a case report and literature review to complement the diagnostic evaluation and management of SAT during pregnancy.Case presentationA 27-year-old woman presented in gestational week 17 of her first pregnancy and had a negative prior medical history. She presented to the Endocrinology Department complaining of neck pain for one month that had intensified in the last five days. Physical examination revealed a diffusely enlarged thyroid gland that was firm and tender on palpation. The patient also had an elevated temperature and heart rate. The increasing and long-lasting pain coupled with a decreased level of thyroid-stimulating hormone indicated hyperthyroidism. Ultrasound findings were indicative of SAT. Importantly, the pain was so severe that 10 mg of oral prednisone per day was administered in gestational week 18, which was increased to 15 mg/d after 10 days that was discontinued in week 28. Levothyroxine was started in gestational week 24 and administered throughout the pregnancy. The patient responded well to the treatments, and her neck pain disappeared in gestational week 21. She gave birth to a healthy male in gestational week 41.ConclusionSAT can be diagnosed and effectively managed during pregnancy, thus benefiting mothers and infants.

【 授权许可】

CC BY