Prenatal prediction of neonatal respiratory morbidity: a radiomics method based on imbalanced few-shot fetal lung ultrasound images

BMC Medical Imaging

Xiaokang Li¹  Yi Guo¹  Jing Jiao¹  Yuanyuan Wang¹  Yunyun Ren²  Yanran Du³ 

[1] Department of Electronic Engineering, Fudan University, No. 220, Handan Road, Yangpu District, 200433, Shanghai, China;Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, 200433, Shanghai, China;Department of Ultrasound, Obstetrics and Gynecology Hospital of Fudan University, No. 128, Shenyang Road, 200090, Shanghai, China;Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197 Rui Jin 2nd Road, 200025, Shanghai, China;

关键词: Neonatal respiratory distress syndrome;    Transient tachypnea;    Prenatal ultrasonic diagnosis;    Fetal lung ultrasound image;    Class imbalance;    Ensemble learning;   

DOI  :  10.1186/s12880-021-00731-z

来源: Springer

【 摘 要 】

BackgroundTo develop a non-invasive method for the prenatal prediction of neonatal respiratory morbidity (NRM) by a novel radiomics method based on imbalanced few-shot fetal lung ultrasound images.MethodsA total of 210 fetal lung ultrasound images were enrolled in this study, including 159 normal newborns and 51 NRM newborns. Fetal lungs were delineated as the region of interest (ROI), where radiomics features were designed and extracted. Integrating radiomics features selected and two clinical features, including gestational age and gestational diabetes mellitus, the prediction model was developed and evaluated. The modelling methods used were data augmentation, cost-sensitive learning, and ensemble learning. Furthermore, two methods, which embed data balancing into ensemble learning, were employed to address the problems of imbalance and few-shot simultaneously.ResultsOur model achieved sensitivity values of 0.82, specificity values of 0.84, balanced accuracy values of 0.83 and area under the curve values of 0.87 in the test set. The radiomics features extracted from the ROIs at different locations within the lung region achieved similar classification performance outcomes.ConclusionThe feature set we designed can efficiently and robustly describe fetal lungs for NRM prediction. RUSBoost shows excellent performance compared to state-of-the-art classifiers on the imbalanced few-shot dataset. The diagnostic efficacy of the model we developed is similar to that of several previous reports of amniocentesis and can serve as a non-invasive, precise evaluation tool for NRM prediction.

【 授权许可】

CC BY