Systematic analysis of the role of SLC52A2 in multiple human cancers

Cancer Cell International

Zhoujun Cui¹  Weixing Wang²  Chen Chen²  Dongqi Chai³  Yongjun Guan³  Man Li³  Lilong Zhang³ 

[1] Department of General Surgery, People’s Hospital of Rizhao, 126 Tai’an Road, Donggang District, 276800, Rizhao, Shandong Province, China;Department of General Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuchang District, 430060, Wuhan, Hubei Province, China;Department of General Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuchang District, 430060, Wuhan, Hubei Province, China;Central Laboratory, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuchang District, 430060, Wuhan, Hubei Province, China;

关键词: SLC52A2;    Pan-cancer;    Hepatocellular;    Carcinoma;    Bioinformatics;    Prognosis;   

DOI  :  10.1186/s12935-021-02432-7

来源: Springer

【 摘 要 】

BackgroundIn humans, riboflavin must be obtained through intestinal absorption because it cannot be synthesized by the body. SLC52A2 encodes a membrane protein belonging to the riboflavin transporter protein family and is associated with a variety of diseases. Here, we systematically explore its relevance to multiple human tumors.MethodsWe analyzed the association of SLC52A2 with 33 tumors using publicly available databases such as TCGA and GEO. We verified the SLC52A2 expression in hepatocellular carcinoma, gastric cancer, colon cancer, and rectal cancer using immunohistochemistry.ResultsWe report that SLC52A2 was highly expressed in almost all tumors, and the immunohistochemical results in the hepatocellular, gastric, colon, and rectal cancers were consistent with the above. SLC52A2 expression was linked to patient overall survival, disease-specific survival, progression-free interval, diagnosis, mutations, tumor mutational burden, microsatellite instability, common immune checkpoint genes, and immune cells infiltration. Enrichment analysis showed that SLC52A2 was mainly enriched in oocyte meiosis, eukaryotic ribosome biogenesis, and cell cycle. In hepatocellular carcinoma, the SLC52A2 expression is an independent prognostic factor. The SNHG3 and THUMPD3-AS1/hsa-miR-139-5p-SLC52A2 axis were identified as potential regulatory pathways in hepatocellular carcinoma.ConclusionIn conclusion, we have systematically described for the first time that SLC52A2 is closely associated with a variety of tumors, especially hepatocellular carcinoma.

【 授权许可】

CC BY