18F-FDG PET/CT image findings of a dog with adrenocortical carcinoma

BMC Veterinary Research

Dongwoo Chang¹  Hakhyun Kim²  Yeon Chae²  Mhan-Pyo Yang²  Taesik Yun²  Byeong-Teck Kang²  Dohee Lee²  Yoonhoi Koo² 

[1] Department of Veterinary Imaging, Veterinary Teaching Hospital, College of Veterinary Medicine, 28644, Cheongju, Chungbuk, South Korea;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, 28644, Cheongju, Chungbuk, South Korea;

关键词: Adrenocortical carcinoma;    Adrenal tumor;    Canine;    Fluorodeoxyglucose;    Positron emission tomography;   

DOI  :  10.1186/s12917-021-03102-6

来源: Springer

【 摘 要 】

BackgroundIn human medicine, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been used to differentiate between benign and malignant adrenal tumors and to identify metastases. However, canine adrenocortical carcinomas identified by 18F-FDG PET/computed tomography (CT) have not been reported.Case presentationA 13-year-old, castrated male, Cocker Spaniel dog with severe systolic hypertension exhibited an adrenal mass approximately 3.6 cm in diameter on ultrasonography. There was no evidence of pulmonary metastasis or vascular invasion on thoracic radiography and abdominal ultrasonography, respectively. 18F-FDG PET/CT was performed to identify the characteristics of the adrenal mass and the state of metastasis. One hour after injection of 5.46 MBq/kg 18F-FDG intravenously, the peripheral region of the adrenal mass visually revealed an increased 18F-FDG uptake, which was higher than that of the liver, and the central region of the mass exhibited necrosis. The maximal standardized uptake value (SUV) of the adrenal mass was 3.24; and relative SUV, calculated by dividing the maximal SUV of the adrenal tumor by the mean SUV of the normal liver, was 5.23. Adrenocortical carcinoma was tentatively diagnosed and surgical adrenalectomy was performed. Histopathologic examination of the resected adrenal mass revealed the characteristics of an adrenocortical carcinoma. After adrenalectomy, systolic blood pressure reduced to below 150 mmHg without any medication.ConclusionThis is the first case report of 18F-FDG PET/CT findings in a dog with suspected adrenocortical carcinoma and may provide valuable diagnostic information for adrenocortical carcinoma in dogs.

【 授权许可】

CC BY