A comparison of the 33-item Hypomania Checklist with the 33-item Hypomania Checklist-external assessment for the detection of bipolar disorder in adolescents

International Journal of Bipolar Disorders

Gabor S. Ungvari¹  Teris Cheung²  Xu Chen³  Sha Sha³  Yuan Feng³  Na Zhao⁴  Yu-Tao Xiang⁵  Wei Bai⁵  Jules Angst⁶ 

[1]Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia

[2]Section of Psychiatry, University of Notre Dame Australia, Fremantle, Australia

[3]School of Nursing, Hong Kong Polytechnic University, Hong Kong SAR, China

[4]The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, School of Mental Health, Xicheng District, 100088, Beijing, China

[5]Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China

[6]Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China

[7]Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China

[8]Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China

[9]Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China

[10]Zurich University Psychiatric Hospital, P.O. Box 8032, Lenggstrasse 31, Zurich, Switzerland

关键词: Adolescents;    Bipolar disorder;    HCL-33;    Self-assessment;    External assessment;   

DOI  :  10.1186/s40345-021-00246-0

来源: Springer

【 摘 要 】

BackgroundAdolescents with bipolar disorder (BD) are often misdiagnosed as having major depressive disorder (MDD), which delays appropriate treatment and leads to adverse outcomes. The aim of this study was to compare the performance of the 33-item Hypomania Checklist (HCL-33) with the 33-item Hypomania Checklist- external assessment (HCL-33-EA) in adolescents with BD or MDD.Methods147 adolescents with BD and 113 adolescents with MDD were consecutively recruited. The HCL-33 and HCL-33-EA were completed by patients and their carers, respectively. The sensitivity, positive predictive value (PPV), specificity, negative predictive value (NPV), and area under the curve (AUC) were calculated and compared between the two instruments, using cut-off values based on the Youden’s index.ResultsThe total scores of the HCL-33 and HCL-33-EA were positively and significantly correlated (rs = 0.309, P < 0.001). Compared to the HCL-33, the HCL-33-EA had higher sensitivity and NPV (HCL-33: sensitivity = 0.58, NPV = 0.53; HCL-33-EA: sensitivity = 0.81, NPV = 0.60), while the HCL-33 had higher specificity and PPV (HCL-33: specificity = 0.61, PPV = 0.66; HCL-33-EA: specificity = 0.37, PPV = 0.63).ConclusionBoth the HCL-33 and HCL-33-EA seem to be useful for screening depressed adolescents for BD. The HCL-33-EA would be more appropriate for distinguishing BD from MDD in adolescents due to its high sensitivity in Chinese clinical settings.

【 授权许可】

CC BY