Electroencephalography-demonstrated mechanisms of dexmedetomidine-mediated deepening of propofol anesthesia: an observational study

Perioperative Medicine

Lei Wang¹  Yuanyuan Cao¹  Lei Zhang¹  Erwei Gu¹  Shengwei Tao²  Liyun Deng²  Hua Li²  Kun Fang²  Fengqiong Yu³ 

[1] Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China;Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China;First School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China;School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, China;

关键词: Anesthesia monitoring;    Anesthesia depth;    Electroencephalogram;    Dexmedetomidine;    Propofol;   

DOI  :  10.1186/s13741-021-00213-4

来源: Springer

【 摘 要 】

BackgroundAlthough dexmedetomidine (Dex) is known to reduce bispectral index (BIS) values and propofol dosage, there is little information regarding raw electroencephalography (EEG) changes related to Dex deepening of propofol general anesthesia (GA). This study investigated the Dex effects on propofol GA via analysis of EEG changes.MethodsA study cohort of 21 surgical patients (age range, 20–60 years) categorized as American Society of Anesthesiologists (ASA) class I or II was enrolled. We used time-varying spectral and bicoherence methods to compare electroencephalogram signatures 5 min before versus 10 min after intravenous Dex injection under propofol GA. The means and medians are reported with 95% confidence intervals (CIs) and inter-quartile ranges (IQRs), respectively.ResultsDex augmented the slow waves power and theta (θ) oscillation bicoherence peak from a mean (95% CI) of 22.1% (19.0, 25.2) to 25.2% (21.8, 28.6). Meanwhile, Dex reduced alpha (α) peak power and bicoherence from 3.5 dB (1.0, 6.0) and 41.5% (34.0, 49.0) to 1.7 dB (− 0.6, 4.0) and 35.4% (29.0, 41.8), respectively, while diminishing the median frequency of α oscillation peak values and the mean frequency of α peaks in bicoherence spectra from 12.0 Hz (IQR 11.2, 12.6) and 11.7 Hz (11.3, 12.2) to 11.1 Hz (IQR 10.3, 11.8) and 11.2 Hz (10.9, 11.6), respectively.ConclusionsProfound EEG changes support the supposition that Dex enhances propofol-induced GA from a moderate to a deeper state. The present findings provide a theoretical basis and reference regarding protocols aimed at reducing anesthetic/sedative dosage while maintaining sufficient depth of GA.Clinical trial registrationChiCTR, ChiCTR1900026955. Registered on 27 October 2019

【 授权许可】

CC BY