Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection

BMC Anesthesiology

Wenkao Huang¹  Yunsheng Li²  Lijun Niu²  Lihong Chen³  Yanhua Luo⁴ 

[1] Department of Anesthesiology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, China;Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University No.58, Zhongshan 2nd Road, 510080, Guangzhou, China;Department of Anesthesiology, The Six Affiliated Hospital, Sun Yat-sen University No. 26, Erheng Road, 510655, Guangzhou, China;Department of Anesthesiology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.54 Xianlie South Road, 510060, Guangzhou, China;

关键词: Deep infiltrating endometriosis;    Morphine;    Oxycodone;    Postoperative analgesia;    Visceral pain;   

DOI  :  10.1186/s12871-021-01417-3

来源: Springer

【 摘 要 】

BackgroundThe objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection.MethodsFifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded.ResultsOxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01).ConclusionOxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine.Name of the registry: Chinese Clinical Trial RegistryTrial registration number: ChiCTR1900021870URL of trial registry record:http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4Date of registration: 2019/3/13 0:00:00

【 授权许可】

CC BY