Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection

Molecular Medicine

Svetlana P. Chapoval¹  Achsah D. Keegan² 

[1] Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA;Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, 21201, Baltimore, MD, USA;Program in Oncology at the Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA;SemaPlex LLC, Ellicott City, MD, USA;Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA;Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, 21201, Baltimore, MD, USA;Program in Oncology at the Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA;VA Maryland Health Care System, Baltimore VA Medical Center, Baltimore, MD, USA;

关键词: ACE2, angiotensin converting enzyme 2;    NRP-1, neuropilin-1;    Molecular structures;    SARS-CoV-2, severe acute respiratory syndrome coronavirus 2;    Spike protein;    COVID-19, coronavirus disease 2019;    Host immune response;    Immunotargets and strategies;    Comorbidities;    CendR C-end rule;    RBD, receptor-biding domain;   

DOI  :  10.1186/s10020-021-00423-y

来源: Springer

【 摘 要 】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike–NRP1 interaction to combat virus infectivity and severe disease manifestations.

【 授权许可】

CC BY