Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality

Gut Pathogens

Yanhong Ouyang¹  Edward Shen²  Ziyang Feng³  Ying Han⁴  Yihan Liu⁵  Cao Guo⁵  Xiangyang Zhang⁵  Changjing Cai⁵  Hong Shen⁶ 

[1] Department of Emergency, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, 19 Xiuhua Road, 570311, Haikou, Hainan, China;Department of Life Science, McMaster University, L8S 4L8, Hamilton, ON, Canada;Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, China;Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China;Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;

关键词: Gut microbiota;    Colorectal cancer;    COVID-19;    Mortality;    Prognosis;   

DOI  :  10.1186/s13099-021-00466-w

来源: Springer

【 摘 要 】

BackgroundCOVID-19 pandemic is sweeping across the world. Previous studies have shown that gut microbiota is associated with COVID-19, and operational taxonomic unit (OTU) composed of Blautia genus, Lactobacillus genus, and Ruminococcus genus of Firmicutes is correlated with the severity of COVID-19. Gut microbiota imbalance in colorectal cancer patients may lead to the variation of OTU.ResultsBased on the GMrepo database, the gut microbiota of 1374 patients with colorectal neoplasms and 27,329 healthy people was analyzed to investigate the differences in the abundance of microbes between colorectal neoplasms patients and healthy people. Furthermore, We collected feces samples from 12 patients with colorectal cancer and 8 healthy people in Xiangya hospital for metabolomic analysis to investigate the potential mechanisms. Our study showed that the abundance of Blautia and Ruminococcus was significantly increased in colorectal neoplasms, which may increase the severity of COVID-19. The gender and age of patients may affect the severity of COVID-19 by shaping the gut microbiota, but the BMI of patients does not.ConclusionsOur work draws an initial point that gut microbiota imbalance is a risk factor of COVID-19 mortality and gut microbiota may provide a new therapeutic avenue for colorectal cancer patients.

【 授权许可】

CC BY