期刊论文详细信息
BMC Psychiatry
Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese
Keshen Li1  Jiawu Fu2  Dong Lv3  Susu Xiong3  Dandan Zhang3  Qian Peng3  Ying Wang3  Zhixiong Lin3  Juda Lin3  Zhun Dai3  Jingwen Yin3  Lulu Wang3  Xudong Luo3  Xiaoqing Ye3  Yaxue Wei4  Guoda Ma5  Yi Qi6  Qianxing Lin6  Fengyan Yu7 
[1] Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China;Clinical Neuroscience Institute of Jinan University, 510630, Guangzhou, China;Department of Neurology, Affiliated Hospital of Guangdong Medical University, 524001, Zhanjiang, China;Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, 524001, Zhanjiang, China;Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, 524001, Zhanjiang, China;Psychiatric and Psychological Clinical Rehabilitation Center, The People’s Hospital of Guangxi Zhuang Autonomous Region, 530021, Nanning, China;Maternal and Children’s Health Research Institute, Shunde Maternal and Children’s Hospital, Guangdong Medical University, 528300, Foshan, China;The Marine Biomedical Research Institute, Guangdong Medical University, 524023, Zhanjiang, China;The Second Clinical School, Guangdong Medical University, 523808, Dongguan, China;
关键词: Schizophrenia;    Long intergenic noncoding RNA 01080 (linc01080);    SNP rs7990916;    Age of onset;    Neurocognitive function;   
DOI  :  10.1186/s12888-021-03623-2
来源: Springer
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【 摘 要 】

BackgroundSchizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of schizophrenia, with a view to providing data support for the prevention and individualized treatment of this disease.MethodThe SNP rs7990916 in linc01080 were genotyped in 1139 schizophrenic and 1039 controls in a Southern Chinese Han population by the improved multiplex ligation detection reaction (imLDR) technique. Meanwhile, we assessed and analyzed the association between this SNP and schizophrenics’ clinical symptoms, and the cognitive function.ResultThere was no significant difference in genotype distribution, allele frequency distribution, gender stratification analysis between the two groups. However, the SNP of rs7990916 was significantly associated with the age of onset in patients with schizophrenia (P = 8.22E-07), patients with T allele had earlier onset age compared with CC genotype carriers. In terms of cognitive function, patients with T allele scored lower than CC genotype carriers in the Tower of London score and symbol coding score in the Brief assessment of Cognition (BACS), and the difference was statistically significant (P = 0.014, P = 0.022, respectively).ConclusionOur data show for the first time that linc01080 polymorphism may affect the age of onset and neurocognitive function in patients with schizophrenia.

【 授权许可】

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