Sarcopenia and coronary heart disease synergistically increase the risk of new onset depressive symptoms in older adults

BMC Geriatrics

Hong Bing Wang¹  Peipei Han²  Yisong Zhang²  Qi Guo²  Jinghuan Liu²  Jiejiao Zheng²  Xing Yu²  Jiawei Tang²  Yong Zhao²  Lixi Chu²  Yuewen Liu²  Xiaoyu Chen³  Yuanyuan Zhang⁴  Peiyu Song⁴ 

[1] Department of Rehabilitation Medicine, Shanghai Fourth Rehabilitation Hospital, 200040, Shanghai, China;Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, 201318, Shanghai, China;Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, 201318, Shanghai, China;Department of Rehabilitation Medicine, Tianjin Medical University, 300070, Tianjin, China;Department of Rehabilitation Medicine, Tianjin Medical University, 300070, Tianjin, China;

关键词: Coronary heart disease;    Depressive symptoms;    Elderly;    Sarcopenia;   

DOI  :  10.1186/s12877-021-02710-z

来源: Springer

【 摘 要 】

BackgroundCoronary heart disease (CHD), sarcopenia and depression are common disorders that markedly impair quality of life and impose a huge financial burden on society. They are also frequently comorbid, exacerbating condition and worsening prognosis. This study aimed to investigate the additive effects of CHD and sarcopenia on the risk of new onset depressive symptoms in older adults.MethodsThe prospective cohort study comprised 897 Chinese community-dwelling participants who were aged 60 years and older (386 men; mean age 66.9 ± 5.9 years) without depressive symptoms at baseline, recruited from Chadian of Tianjin, China. Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) criteria. CHD was identified via medical records or new diagnosed by at least two physicians. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) ≥11. Longitudinal data on new onset depressive symptoms were collected up to 12 months after baseline.ResultsWe found that 103 (11.5%) of the 897 participants without depressive symptoms at baseline had developed depressive symptoms. Participants were classified into mutually exclusive groups based on sarcopenia status and CHD: normal, CHD alone, sarcopenia alone, and co-occurring groups. A logistic regression showed that the CHD alone [odd ratios (OR) = 1.78, 95% confidence interval (CI) = 1.05–3.02], sarcopenia alone (OR = 2.79, 95% CI = 1.26–6.22), and co-occurring (OR = 7.19, 95% CI = 2.75–18.81) had higher risk of depressive symptoms than the normal group after adjusting for the covariates.ConclusionsCHD and sarcopenia synergistically increase the risk of new onset depressive symptoms in older adults. Thus, older adults may require early detection, and appropriate interventions should be implemented.

【 授权许可】

CC BY