A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains

European Journal of Medical Research

Ryota Matsuoka¹  Masayuki Noguchi¹  Noriaki Sakamoto¹  Shigeru Chiba²  Takayasu Kato² 

[1] Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8577, Tsukuba, Ibaraki, Japan;Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8577, Tsukuba, Ibaraki, Japan;

关键词: Solitary plasmacytoma of bone;    Dual immunoglobulin light chain expression;    Allelic exclusion;    Isotypic exclusion;    Case report;   

DOI  :  10.1186/s40001-021-00621-8

来源: Springer

【 摘 要 】

BackgroundSolitary plasmacytoma of bone (SPB) is a rare plasma cell neoplasm. It arises in bone as a single locus in the absence of any plasma cell myeloma lesions. Plasma cell neoplasms intrinsically express only one immunoglobulin light chain (IgL)—kappa or lambda—and using this fact, kappa/lambda deviation is the decisive factor for diagnosis. Co-expression of both IgLs in a single tumor cell is extremely rare.Case presentationWe report a case of SPB that arose in the vertebra of a 52-year-old Japanese woman. Histologically, the resected mass showed diffuse plasma cell proliferation. Dual IgL expression was detected by flow cytometry, immunohistochemistry, and in situ hybridization (ISH) targeting IgL mRNA.ConclusionWe have presented an extremely rare case of SPB showing dual expression of kappa and lambda IgLs. This unusual case of plasma cell neoplasia might represent a possible exceptional example of failure of “IgL isotypic exclusion.”

【 授权许可】

CC BY