Real Nano “Light Vaccine” Will Benefit to COVID-19 Pandemic Control

Nano-Micro Letters

Jianshe Yang¹ 

[1] Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072, Shanghai, People’s Republic of China;

关键词: SARS-CoV-2;    COVID-19;    Light;    Vaccine;    Photothermal conversion;    Nanomaterial;   

DOI  :  10.1007/s40820-021-00723-2

来源: Springer

【 摘 要 】

This highlight presents a recent technique of “Light Vaccine” for COVID-19 pandemic control. Though this technique has the germicidal advantage to SARS-CoV-2, its shortcomings will limit the wide and in-depth application. We make a perspective of real nano light vaccine, which will play an important role in the prevention and control of COVID-19. Briefly, This flow chart described the MWCNT was fabricated with strong acid and base conditional mixture in order to achieve the p-WCNT (chemical process); then modified with RNA layse and receptor binding domain (RBD) by covalent conjugation and physical absorption to get f-WCNT (functionalization); thereafter, f-WCNT was used in the multi-cell culture system interacting with SARS-CoV-2 to identify the special affinity of f-WCNT to ACE2 labeled alveolar type II cells and the inhibition capacity to SARS-CoV-2. This design, is different from the so called “light vaccine”, has the real function to against SARS-CoV-2 by local cellular temperature-rising through photothermal conversion under the near infrared (NIR) light irradiation, according to the physical and chemical nature of carbon nanotubes, and initiates the immune response consequently.

【 授权许可】

CC BY