Epigenetics in neurodegenerative disorders induced by pesticides

Genes and Environment

Siying Wu¹  Qianqian Su²  Lingyan Wu²  Yao Chen²  Huangyuan Li³  Guangxia Yu³ 

[1] Fujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Fujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Fujian Key Lab of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;Key Lab of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China;

关键词: Neurodegenerative disease;    Epigenetic;    Nervous system;    Environmental pollution;    Pesticide;    DNA methylation;    Histone modifications;    Non-coding RNA;    RNA methylation;    N6-methyladenosine;   

DOI  :  10.1186/s41021-021-00224-z

来源: Springer

【 摘 要 】

Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epigenetic changes and inducing disruption of the epigenome. This review summaries studies on epigenetics alterations in nervous systems in relation to different kinds of pesticides, highlighting potential mechanism in the etiology, precision prevention and target therapy of various neurodegenerative diseases. In addition, the current gaps in research and future areas for study were also discussed.

【 授权许可】

CC BY