Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways

BMC Cardiovascular Disorders

Jia-Qi Dong¹  Guo-An Zhao¹  Jie Zhang²  Lei Wang³  Lu-Yang Jiao³  De-Ying Bo³  Guang-Jian Lu³  Ming-Zhang Xie³  Ke-Tao Sun⁴  Chun Guo⁵ 

[1] Department of Cardiovascular, First Affiliated Hospital of Xinxiang Medical University, 453000, Xinxiang, Henan, People’s Republic of China;Department of Integrating Western and Chinese of Internal Medicine, First Affiliated Hospital of Xinxiang Medical University, 453000, Xinxiang, Henan, People’s Republic of China;Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, 453000, Xinxiang, Henan, People’s Republic of China;Department of Laboratory, Zibo Central Hospital, 255036, Zibo, Shandong, People’s Republic of China;Henan Key Laboratory of Neural Regeneration (Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia), First Affiliated Hospital of Xinxiang Medical University, 453000, Xinxiang, Henan, People’s Republic of China;

关键词: Cardiovascular diseases;    Human aortic endothelial cells;    Mitogen-activated protein kinase pathways;    Glyoxal;    Laboratory indexes;   

DOI  :  10.1186/s12872-021-02418-3

来源: Springer

【 授权许可】

CC BY