Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis

Diagnostic Pathology

Changhua Zhang¹  Jun Ouyang²  Xiaokun Wang²  Yawei Zhang²  Xinhua Zhang³  Tailai An⁴  Xiaofang Lu⁵  Yan Wang⁶ 

[1] Center of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China;Center of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China;Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road 58, Yuexiu District, Guangzhou, Guangdong, China;Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road 58, Yuexiu District, Guangzhou, Guangdong, China;Department of Hepatobiliary and Pancreatic Surgery, Shenzhen People’s Hospital, Shenzhen, Guangdong, China;Department of Pathology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China;Department of Radiology, Shenzhen People’s Hospital, Shenzhen, Guangdong, China;

关键词: Gastrointestinal stromal tumor;    SOCS6;    Overall survival;    Recurrence-free survival;    Cox proportional regression model analysis;   

DOI  :  10.1186/s13000-021-01172-6

来源: Springer

【 摘 要 】

BackgroundMany studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of malignant tumors have been published. The present study was performed to evaluate whether SOCS6 was significantly associated with prognosis of GIST patients.MethodsImmunohistochemical staining was accomplished to evaluate the expression levels of SOCS6 among GIST patients. The impacts of SOCS6 expression on overall survival (OS) and recurrence-free survival (RFS) of GIST patients were assessed by Cox proportional hazard regression model analysis and Kaplan-Meier curve analysis.ResultsIt was demonstrated that the expression level of SOCS6 was significantly associated with tumor size (P=0.001). Then according to Kaplan-Meier curve analysis, low expression of SOCS6 was significantly correlated with worse OS and RFS of GIST patients. Ultimately, it was revealed by Cox proportional regression model analysis that low expression of SOCS6 was an independent predictive factor for OS and RFS.ConclusionsLow expression of SOCS6 was an independent prognostic factor for GIST, suggesting its potential as a novel biomarker predicting survival of GIST patients.

【 授权许可】

CC BY