Tumor-derived biomimetic nanozyme with immune evasion ability for synergistically enhanced low dose radiotherapy

Journal of Nanobiotechnology

Shuntao Wang¹  Chunping Liu¹  Yongfa Zheng²  Zeming Liu³  Wei Liu⁴  Chunyu Huang⁴  Mingzhu Chen⁴  Liang Du⁴ 

[1] Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China;Department of Oncology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, China;Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China;Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, 430072, Wuhan, People’s Republic of China;

关键词: Low-dose radiotherapy;    Tumor-derived exosomes;    Pyrite nanozyme;    Mitochondrial damage;    GSH depletion;   

DOI  :  10.1186/s12951-021-01182-y

来源: Springer

【 摘 要 】

High doses of radiation can cause serious side effects and efficient radiosensitizers are urgently needed. To overcome this problem, we developed a biomimetic nanozyme system (CF) by coating pyrite (FeS2) into tumor-derived exosomes for enhanced low-dose radiotherapy (RT). CF system give FeS2 with immune escape and homologous targeting abilities. After administration, CF with both glutathione oxidase (GSH-OXD) and peroxidase (POD) activities can significantly lower the content of GSH in tumor tissues and catalyze intracellular hydrogen peroxide (H2O2) to produce a large amount of ·OH for intracellular redox homeostasis disruption and mitochondria destruction, thus reducing RT resistance. Experiments in vivo and in vitro showed that combining CF with RT (2 Gy) can provide a substantial suppression of tumor proliferation. This is the first attempt to use exosomes bionic FeS2 nanozyme for realizing low-dose RT, which broaden the prospects of nanozymes.Graphical Abstract

【 授权许可】

CC BY