Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis

Lipids in Health and Disease

Arturo González-Quintela¹  Joaquín Campos-Franco¹  Emilio-Manuel Páez-Guillán¹  Yago Garitaonaindía¹  Rosario Alende¹ 

[1] Department of Internal Medicine, Complejo Hospitalario Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain;

关键词: Epstein-Barr virus;    Infectious mononucleosis;    Dyslipidemia;    Hypertriglyceridemia;   

DOI  :  10.1186/s12944-021-01603-9

来源: Springer

【 摘 要 】

BackgroundHypertriglyceridemia can occur in lymphoproliferative disorders. Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis.MethodsWe evaluated an adult patient with severe hypertriglyceridemia (>1000 mg/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (n=75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients.ResultsThe triglyceride concentrations in the acute phase (median: 156 mg/dL) were significantly higher than those of the controls (median, 76 mg/dL; P<0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (>150 mg/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%; P<0.001). A significant correlation (P<0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (P<0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P<0.001).ConclusionsPatients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.

【 授权许可】

CC BY