Activity of terpenes derived from essential oils against Sarcoptes scabiei eggs

Parasites & Vectors

Charlotte Bernigaud¹  Jacques Guillot²  Zhijuan Yin³  Fang Fang³  Meilin Li³  Shunlong Liu³ 

[1] Dynamic, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est Créteil (UPEC), 7 Avenue du Général de Gaulle, 94700, Maisons-Alfort, France;Dermatology Department, Faculté de Santé, Hôpital Henri Mondor–Université Paris-Est Créteil, Assistance Publique–Hôpitaux de Paris (AP-HP), Créteil, France;Dynamic, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est Créteil (UPEC), 7 Avenue du Général de Gaulle, 94700, Maisons-Alfort, France;Dermatology Parasitology Mycology Department, Ecole Nationale Vétérinaire , Agroalimentaire et de l’Alimentation (ONIRIS), Nantes, France;Parasitology Department, College of Animal Science and Technology, Guangxi University, Nanning, China;

关键词: Sarcoptes scabiei;    Scabies;    Essential oil;    Terpenes;    Ovicidal activity;   

DOI  :  10.1186/s13071-021-05094-6

来源: Springer

【 摘 要 】

BackgroundThe limited ovicidal activity of currently available acaricides is a significant obstacle to efficacious scabies treatment. Several essential oils or their respective components have proved to be active against the eggs of arthropods, mainly lice and ticks. Information on the activity of these oils and/or components against the eggs of mites remains very limited. The aim of this study was to assess the activity of six terpenes (carvacrol, eugenol, geraniol, citral, terpinen-4-ol and linalool) commonly found in essential oils against the eggs of Sarcoptes scabiei.MethodsSarcoptes eggs were exposed to paraffin oil containing 1, 2.5, or 5% of each terpene tested. After a 12-h exposure period, the eggs were washed and placed in paraffin oil for hatching. Embryonic development following treatment was assessed every day to determine the stage of developmental arrest.ResultsThe median effective concentration to obtain 50% egg mortality (EC50) was 0.5, 0.9, 2.0, 4.8, 5.1 and 9.8% for carvacrol, eugenol, geraniol, citral, terpinen-4-ol and linalool, respectively. The microscopic images of eggs after each treatment indicated that these six terpenes may act by penetrating through the aeropyles on the egg surface.ConclusionsIn conclusion, carvacrol, eugenol and geraniol possess significant ovicidal activities, which should be considered as promising ovicidal agents for the treatment of scabies.Graphical Abstract

【 授权许可】

CC BY