A scalable approach to topographically mediated antimicrobial surfaces based on diamond

Journal of Nanobiotechnology

David J. Schultz¹  Hyun Jin Jung¹  Jesse L. Rozsa¹  Mark P. Running¹  William F. Paxton²  Jacek B. Jasinski²  Muhammad Zain Akram³  Morgan M. Brooks⁴ 

[1] 219 Life Sciences Building, University of Louisville, 40292, Louisville, KY, USA;Conn Center for Renewable Energy Research, University of Louisville, 40292, Louisville, KY, USA;Kentucky Advanced Materials Manufacturing, 40209, Louisville, KY, USA;LSU School of Medicine, 1542 Tulane Ave, 70112, New Orleans, LA, USA;

关键词: Topographically mediated surfaces;    Diamond;    Nanoneedles;    Nanospikes;    Antimicrobial;    CVD;   

DOI  :  10.1186/s12951-021-01218-3

来源: Springer

【 摘 要 】

Bio-inspired Topographically Mediated Surfaces (TMSs) based on high aspect ratio nanostructures have recently been attracting significant attention due to their pronounced antimicrobial properties by mechanically disrupting cellular processes. However, scalability of such surfaces is often greatly limited, as most of them rely on micro/nanoscale fabrication techniques. In this report, a cost-effective, scalable, and versatile approach of utilizing diamond nanotechnology for producing TMSs, and using them for limiting the spread of emerging infectious diseases, is introduced. Specifically, diamond-based nanostructured coatings are synthesized in a single-step fabrication process with a densely packed, needle- or spike-like morphology. The antimicrobial proprieties of the diamond nanospike surface are qualitatively and quantitatively analyzed and compared to other surfaces including copper, silicon, and even other diamond surfaces without the nanostructuring. This surface is found to have superior biocidal activity, which is confirmed via scanning electron microscopy images showing definite and widespread destruction of E. coli cells on the diamond nanospike surface. Consistent antimicrobial behavior is also observed on a sample prepared seven years prior to testing date.Graphical Abstract

【 授权许可】

CC BY