The efficacy and safety of antimuscarinics for the prevention or treatment of catheter-related bladder discomfort: a systematic review and meta-analysis of randomized controlled trials

Perioperative Medicine

Zhongbao Zhou¹  Yong Zhang¹  Yuanshan Cui²  Xiaoyi Zhang³  Youyi Lu⁴  Zhipeng Chen⁵ 

[1] Department of Urology, Beijing TianTan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, 100070, Beijing, China;Department of Urology, Beijing TianTan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, 100070, Beijing, China;Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000, Yantai, Shandong, China;Department of Urology, PLA Rocket Force Characteristic Medical Center, No. 16 Xinwai Street, Xicheng District, 100088, Beijing, China;Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, 264000, Yantai, Shandong, China;Department of Urology, Weifang People’s Hospital, 261000, Weifang, Shandong, China;

关键词: Antimuscarinics;    Catheter related bladder discomfort;    Randomized controlled trials;    Prevention or treatment;    Systematic review;    Meta-analysis;   

DOI  :  10.1186/s13741-021-00217-0

来源: Springer

【 摘 要 】

ObjectivesThis meta-analysis aimed to evaluate the efficacy and safety of antimuscarinics for the prevention or treatment of catheter related bladder discomfort (CRBD).MethodsThe MEDLINE, EMBASE, and Cochrane Controlled Trials Register (from 1987 to July 2021) were used to search randomized controlled trials. The PRISMA checklists were followed. RevMan5.4.0 was used for statistical analysis.ResultsEleven studies involving 1165 patients were involved in the analysis. The study reported that the incidence of CRBD observed in the antimuscarinics group was significantly lower than that of the control group at 0-, 1-, 2-, and 6-h after drug therapy (P = 0.001, P < 0.0001, P = 0.0005, and P = 0.001, respectively). For side effects, there were not statistical differences between the antimuscarinics group and the control group, mainly including dry mouth (risk ratio (RR) = 1.31, 95% confidence interval (CI) = 0.95 to 1.80, P = 0.09), postoperative nausea and vomiting (RR = 1.02, 95% CI = 0.55 to 1.90, P = 0.87), facial flushing (RR = 1.06, 95% CI = 0.43 to 2.61, P = 0.90), and blurred vision (RR = 0.95, 95% CI = 0.35 to 2.58, P = 0.91). Besides, rescue analgesics were required less in the antimuscarinics group than in the control group (RR = 0.51, 95% CI = 0.32 to 0.80, P = 0.003).ConclusionsCompared with the control group, the antimuscarinics group had a significant improvement on CRBD, the patients were well tolerated and the use rate of rescue analgesics was low.

【 授权许可】

CC BY