17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial

Critical Care

Erik B. Erhardt¹  Irshad H. Chaudry²  Rachel E. Kinsler³  Amy L. Lloyd⁴  Chen Lai⁵  Jessica M. Gill⁵  Vivian A. Guedes⁵  Carissa J. Mehos⁶  Rebecca J. Dodd⁷  Sharvani Pabbathi Reddy⁷  Julie G. Rannou-Latella⁷  Cidney R. Robertson-Benta⁷  Josef M. Ling⁷  Veronik Sicard⁷  Meghan S. Vermillion⁷  David D. Stephenson⁷  Andrew B. Dodd⁷  Andrew P. Gigliotti⁷  Andrew R. Mayer⁸ 

[1]Department of Mathematics and Statistics, University of New Mexico, 87131, Albuquerque, NM, USA

[2]Department of Surgery, University of Alabama at Birmingham, 35294-0019, Birmingham, AL, USA

[3]Department of the Army Civilian, U.S. Army Aeromedical Research Laboratory, 36362-0577, Fort Rucker, AL, USA

[4]Department of the Army Civilian, U.S. Army Aeromedical Research Laboratory, 36362-0577, Fort Rucker, AL, USA

[5]Goldbelt Frontier, Inc., U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, USA

[6]National Institute of Nursing Research, National Institutes of Health, 20892, Bethesda, MD, USA

[7]Neurosciences Department, University of New Mexico School of Medicine, 87131, Albuquerque, NM, USA

[8]The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, 87106, Albuquerque, NM, USA

[9]The Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, 87106, Albuquerque, NM, USA

[10]Neurology Department, University of New Mexico School of Medicine, 87131, Albuquerque, NM, USA

[11]Psychiatry Department, University of New Mexico School of Medicine, 87131, Albuquerque, NM, USA

[12]Psychology Department, University of New Mexico, 87131, Albuquerque, NM, USA

关键词: Hypovolemia;    Brain injuries;    Traumatic;    Estrogens;    Swine;    Hemodynamics;    Multiple trauma;   

DOI  :  10.1186/s13054-021-03844-7

来源: Springer

【 授权许可】

CC BY