Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Journal of Translational Medicine

Fermín Sánchez-Guijo¹  Juan F. Blanco²  Felipe Prósper³  José María Lamo-Espinosa³  Margarita González-Vallinas⁴  Javier García-Sancho⁴  Mercedes Alberca⁴  Verónica García⁴ 

[1] Cell Therapy Area, IBSAL- Salamanca University Hospital, University of Salamanca, Salamanca, Spain;Department of Traumatology, Salamanca University Hospital, Salamanca, Spain;Orthopedic Surgery and Traumatology Department, Clínica Universidad de Navarra, Pamplona, Spain;Hematology and Cell Therapy Department, Clínica Universidad de Navarra, Pamplona, Spain;University of Valladolid (UVa), Valladolid, Spain;Unidad de Excelencia Instituto de Biología Y Genética Molecular (IBGM), UVa-CSIC, Valladolid, Spain;

关键词: Osteoarthritis;    Mesenchymal stem cells;    Intraarticular injection;    Regenerative medicine;    Stem cell therapy;   

DOI  :  10.1186/s12967-021-03160-2

来源: Springer

【 摘 要 】

Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014—Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1

【 授权许可】

CC BY