Incidence and mortality of necrotizing fasciitis in The Netherlands: the impact of group A Streptococcus

BMC Infectious Diseases

Brechje de Gier¹  Rolf H. H. Groenwold²  Diederik A. H. Brandwagt³  Jort Keizer⁴  Femke Nawijn⁵  Falco Hietbrink⁵ 

[1] Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Utrecht, The Netherlands;Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands;Department of Infectious Diseases, Public Health Service (GGD) Region Utrecht, Utrecht, The Netherlands;Department of Surgery, Sint Antonius Hospital, Utrecht, The Netherlands;Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands;

关键词: Necrotizing fasciitis;    Necrotizing soft tissue infection;    Incidence;    The Netherlands;    Mortality;    Health care burden;   

DOI  :  10.1186/s12879-021-06928-5

来源: Springer

【 摘 要 】

BackgroundLittle is known about the exact incidence of necrotizing soft tissue infections. The few incidences reported in international literature are not directly relatable to the Netherlands, or other European countries, due to geographic heterogeneity in causative micro-organisms involved. This resulted in the aim of this study to map the incidence, mortality rate and hospital course of necrotizing fasciitis infections in the Netherlands to gain insight in the incidence of necrotizing fasciitis in the Netherlands and the associated mortality and health care burden.MethodsThis nationwide retrospective database study used three distinct data sources to map the incidence of necrotizing fasciitis in the Netherlands between 2014 and 2019, being data from the Dutch Hospital Data (DHD) foundation, data from Osiris-AIZ, which is a database of notifiable diseases managed by regional Public Health Services (GGD) and the National Institute for Public Health and the Environment (RIVM), and previously published studies on necrotizing fasciitis conducted in the Netherlands.ResultsThe incidence of necrotizing fasciitis in the Netherlands is estimated to be approximately 1.1 to 1.4 cases per 100,000 person years, which corresponds to 193–238 patients per year. Of all necrotizing fasciitis infections, 34 to 42% are caused by the group A Streptococcus. Annually, 56 patients die as a result of a necrotizing fasciitis infection (mortality of 23–29%) and 26 patients undergo an amputation for source control (11–14%). Patients stay a mean of 6 to 7 days at the intensive care unit and have a mean hospital length of stay of 24 to 30 days.ConclusionThe combination of nationwide databases provides reliable insight in the epidemiology of low-incidence and heterogenic diseases. In the Netherlands, necrotizing fasciitis is a rare disease with group A Streptococcus being the most common causative micro-organism of necrotizing fasciitis. The prior Dutch cohort studies on necrotizing fasciitis report slightly higher sample mortality rates, compared to the population mortality. However, necrotizing fasciitis remain associated with substantial morbidity and mortality, risk at amputation and health care burden characterized by prolonged ICU and hospital stay.

【 授权许可】

CC BY