Comparison of the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing in vitro fertilization using a standardized stimulation regime

Journal of Ovarian Research

Jennifer K. Y. Ko¹  Ernest H. Y. Ng¹  Raymond H. W. Li¹  Vivian C. Y. Lee²  Peter Leung³  William Ledger⁴  Andrew Kan⁴ 

[1] Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China;Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China;Premier Medical Centre, Hong Kong, China;IVF Australia, Sydney, Australia;Department of Obstetrics and Gynecology, The University of Sydney, Sydney, Australia;IVF Australia, Sydney, Australia;Discipline of Obstetrics and Gynecology, School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia;

关键词: ethnicity;    ovarian response;    in vitro fertilization;    infertility;    corifollitropin alfa;   

DOI  :  10.1186/s13048-021-00928-4

来源: Springer

【 摘 要 】

BackgroundIn vitro fertilization (IVF) is a well-established method to treat various causes of infertility. Some previous retrospective studies suggested a lower ovarian response in Asian women compared to Caucasian women. However, the ovarian stimulation regimens were not standardized, potentially confounding the findings. The objective of this study is to compare the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing IVF using a standardized stimulation regimen.MethodsThis is a prospective cohort study conducted in two tertiary IVF units in Hong Kong, China and Sydney, Australia from October 2016 to August 2019. A total of 192 women aged 18–42 years with a body weight > 60 kg underwent IVF with a standard ovarian stimulation regimen of 150 micrograms corifollitropin alfa (Elonva®) followed by 200 IU follitropin beta (Puregon®) per day. The number of oocytes retrieved in Chinese women treated in the Hong Kong center was compared to that of Caucasian women treated in the Australian center.ResultsSerum AMH levels were similar between the two groups. Although women in the Chinese cohort were older and had a higher body mass index (BMI), longer duration of infertility and lower antral follicle count (AFC) than those in the Caucasian cohort in this study, no differences in the number of oocytes retrieved [11 (8–17) vs. 11 (6–17), p=0.29], total dosage and duration of stimulation and number of follicles aspirated were noted between the two ethnic cohorts. The peak estradiol level was greater in Chinese women than in Caucasian women. After controlling for age, BMI and AFC, ethnicity was a significant independent determinant of the number of oocytes obtained.ConclusionsChinese women had a higher number of oocytes after ovarian stimulation using a standardized stimulation regimen compared with Caucasian women undergoing IVF after controlling for age, BMI, AFC and AMH despite presenting later after a longer duration of infertility. Trial registration number: NCT02748278

【 授权许可】

CC BY