Intricate crosstalk between MYB and noncoding RNAs in cancer

Cancer Cell International

Jing Liu¹  Shunling Yuan²  Dingyu Hu²  Wenjun Shao²  Li Liu²  Yanyan Wang²  Zhaoping Liu²  Ji Zhang³ 

[1] Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, 410078, Changsha, Hunan, China;The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China;The First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China;Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, 518033, Shenzhen, Guangdong, China;

关键词: MYB;    Noncoding RNAs;    LncRNAs;    MiRNAs;    Tumorigenesis;   

DOI  :  10.1186/s12935-021-02362-4

来源: Springer

【 摘 要 】

MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to tumorigenesis, therefore, different tumor mechanisms produce similar MYB proteins. As MYB is a transcription factor, priority has been given to identifying the genes that it regulates. All previous attention has been focused on protein-coding genes. However, an increasing number of studies have suggested that MYB can affect the complexity of cancer progression by regulating tumor-associated noncoding RNAs (ncRNAs), such as microRNAs, long-non-coding RNAs and circular RNAs. ncRNAs can regulate the expression of numerous downstream genes at the transcription, RNA processing and translation levels, thereby having various biological functions. Additionally, ncRNAs play important roles in regulating MYB expression. This review focuses on the intricate crosstalk between oncogenic MYB and ncRNAs, which play a pivotal role in tumorigenesis, including proliferation, apoptosis, angiogenesis, metastasis, senescence and drug resistance. In addition, we discuss therapeutic strategies for crosstalk between MYB and ncRNAs to prevent the occurrence and development of cancer.

【 授权许可】

CC BY