Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

Nano-Micro Letters

Ying Fu¹  Jason Davis¹  Bowen Shu²  Cheng Jiang³  George K. Tofaris⁴  Guozhen Liu⁵ 

[1] Department of Chemistry, University of Oxford, OX1 3QZ, Oxford, UK;Dermatology Hospital, Southern Medical University, 510091, Guangzhou, People’s Republic of China;Nuffield Department of Clinical Neurosciences, New Biochemistry Building, University of Oxford, OX1 3QU, Oxford, UK;Department of Chemistry, University of Oxford, OX1 3QZ, Oxford, UK;Kavli Institute for Nanoscience Discovery, New Biochemistry Building, University of Oxford, Oxford, UK;Nuffield Department of Clinical Neurosciences, New Biochemistry Building, University of Oxford, OX1 3QU, Oxford, UK;Kavli Institute for Nanoscience Discovery, New Biochemistry Building, University of Oxford, Oxford, UK;School of Life and Health Sciences, The Chinese University of Hong Kong, 518172, Shenzhen, People’s Republic of China;

关键词: Multiplexed profiling;    Extracellular vesicles;    Exosomes;    Liquid biopsy;    Point-of-care;    Biomarker;   

DOI  :  10.1007/s40820-021-00753-w

来源: Springer

【 摘 要 】

tsExtracellular vesicle (EV) multiplexing involves chemical, physical spatial, biological, or nanoparticle-based strategies.Multiplexing in EV biomarker development includes high-throughput screening as well as point-of-care testing platforms which to date have been applied mainly to EV surface proteins or internal cargo miRNAs.Multiplexed measurements at single-EV resolution are likely to revolutionize the applicability of EV analytes as biomarkers in complex and heterogeneous diseases.

【 授权许可】

CC BY