Zeptomole Imaging of Cytosolic MicroRNA Cancer Biomarkers with A Light-Controlled Nanoantenna

Nano-Micro Letters

Grayson Ostermeyer¹  Dan Du²  Shichao Ding²  Xiaoli Cai²  Yuehe Lin²  Yang Song³ 

[1] School of Biological Sciences, Washington State University, 99164, Pullman, WA, USA;School of Mechanical and Materials Engineering, Washington State University, 99164, Pullman, WA, USA;School of Mechanical and Materials Engineering, Washington State University, 99164, Pullman, WA, USA;Nanosong Systems LLC, 98052, Redmond, WA, USA;

关键词: Light-harvest;    Nanoantenna;    miRNA detection;    Zeptomole;    Multiple cell lines;   

DOI  :  10.1007/s40820-021-00732-1

来源: Springer

【 摘 要 】

tsBased on førster resonance energy transfer, the nanoantenna containing over 4000 donor dyes can achieve unprecedented signal amplification and biosensing sensitivity.With light irradiation, the light-harvesting nanoantenna effectively disrupted lysosomal structures by generation of reactive oxygen species, substantially achieved cytosol delivery.The zeptomolar sensitivity of nanoantenna provides accurate bioimaging of miR-210 in multiple cell lines and in vivo assay, which creates a pathway for the creation of miRNA toolbox for quantitative epigenetics and personalized medicine.

【 授权许可】

CC BY