Reproductive history and blood cell DNA methylation later in life: the Young Finns Study

Clinical Epigenetics

Emma Raitoharju¹  Saara Marttila²  Terho Lehtimäki³  Pashupati P. Mishra³  Mika Kähönen⁴  Emily W. Harville⁵  Olli Raitakari⁶ 

[1] Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland;Department of Molecular Epidemiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland;Department of Molecular Epidemiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;Gerontology Research Center, Tampere University, Tampere, Finland;Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland;Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33521, Tampere, Finland;Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland;Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33521, Tampere, Finland;Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 70112, New Orleans, LA, USA;Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland;Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland;

关键词: DNA methylation;    Epigenetics;    Pregnancy;    Reproductive history;    Pre-eclampsia;   

DOI  :  10.1186/s13148-021-01215-1

来源: Springer

【 摘 要 】

BackgroundWomen with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease later in life. We aimed to examine differences in maternal DNA methylation following pregnancy complications.MethodsData on women participating in the Young Finns study (n = 836) were linked to the national birth registry. DNA methylation in whole blood was assessed using the Infinium Methylation EPIC BeadChip. Epigenome-wide analysis was conducted on differential CpG methylation at 850 K sites. Reproductive history was also modeled as a predictor of four epigenetic age indices.ResultsFourteen significant differentially methylated sites were found associated with both history of pre-eclampsia and overall hypertensive disorders of pregnancy. No associations were found between reproductive history and any epigenetic age acceleration measure.ConclusionsDifferences in epigenetic methylation profiles could represent pre-existing risk factors, or changes that occurred as a result of experiencing these complications.

【 授权许可】

CC BY