Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs

Chinese Medicine

Jiang Chen¹  Qinghua Wu¹  Dingkun Zhang¹  Peng Tan¹  Jin Pei¹  Yongfeng Zhou²  Yanzhong Han²  Xiaohe Xiao³  Ping Zhang⁴  Jiaxin Liu⁴  Boyu Xing⁴  Junnan Wang⁵ 

[1] College of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, 611137, Chengdu, Sichuan, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, 611137, Chengdu, Sichuan, China;Department of Pharmacy, Medical Supplies Center of PLA General Hospital, 100#, West 4th Ring Middle Rd., Fengtai, 10039, Beijing, China;Department of Liver Disease, Fifth Medical Center of PLA General Hospital, 100#, West 4th Ring Middle Rd., Fengtai, 10039, Beijing, China;Department of Pharmacy, Medical Supplies Center of PLA General Hospital, 100#, West 4th Ring Middle Rd., Fengtai, 10039, Beijing, China;School of Chinese Pharmacy, Beijing University of Chinese Medicine, 102488, Beijing, China;Department of Pharmacy, Medical Supplies Center of PLA General Hospital, 100#, West 4th Ring Middle Rd., Fengtai, 10039, Beijing, China;

关键词: Natural medicines;    Drug-induced liver injury;    Bioactive components;    Mechanism;   

DOI  :  10.1186/s13020-021-00543-x

来源: Springer

【 摘 要 】

Drug-induced liver injury (DILI) is a common adverse drug reaction (ADR) and a serious threat to health that affects disease treatments. At present, no targeted clinical drugs are available for DILI. Traditional natural medicines have been widely used as health products. Some natural medicines exert specific hepatoprotective effects, with few side effects and significant clinical efficacy. Thus, natural medicines may be a promising direction for DILI treatment. In this review, we summarize the current knowledge, common drugs and mechanisms of DILI, as well as the clinical trials of natural drugs and their bioactive components in anticipation of the future development of potential hepatoprotective drugs.

【 授权许可】

CC BY