Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study

BMC Endocrine Disorders

Kexin Zou¹  Yue Xu²  Jiexue Pan²  Congcong Jin³  Haiyan Yang³ 

[1]Obstetrics & Gynecology Hospital, Institute of Reproduction and Development, Fudan University, 200011, Shanghai, China

[2]Shanghai Key Laboratory of Embryo Original Diseases, 200030, Shanghai, China

[3]Obstetrics & Gynecology Hospital, Institute of Reproduction and Development, Fudan University, 200011, Shanghai, China

[4]Shanghai Key Laboratory of Embryo Original Diseases, 200030, Shanghai, China

[5]Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, 200011, Shanghai, China

[6]The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, China

关键词: Polycystic ovary syndrome;    PTX3;    Hyperandrogenism;    Innate immunology;   

DOI  :  10.1186/s12902-021-00886-4

来源: Springer

【 摘 要 】

BackgroundPentraxin 3 (PTX3) - a crucial humoral innate immunity component – is related to obesity and cardiovascular complications in women who suffer from polycystic ovary syndrome (PCOS). However, the circulating PTX3 level in PCOS is still debated. In this study, we aimed to evaluate PTX3 plasma levels in PCOS women of childbearing age, and find possible endocrine/metabolic factors that could affect this level.MethodsA total of 360 women were enrolled: 120 PCOS women and 240 body mass index (BMI) matched normally ovulating women. Blood samples were collected on the third day of natural menstrual cycle or from the bleeding after progesterone withdrawal. The PTX3 concentration was measured by immunoassay.ResultsThe PTX3 plasma level was significantly higher in PCOS women compared to controls. There was a positive correlation between PTX3 plasma level and PCOS diagnosis, overweight, cycle length, serum LH to FSH ratio, estradiol, total testosterone (TT) on the third day of menstrual cycle, antral follicle count (AFC), as well as uric acid. Multivariant linear regression analysis indicated that participants’ serum PTX3 levels were proportional to the circulating TT level, existence of PCOS, basal estradiol level and AFC.ConclusionsOverall, the circulating PTX3 level was elevated in PCOS women and significantly associated with the presence of hyperandrogenism. This study provided the basis for further in-depth researches regarding PTX3 role in PCOS pathophysiology.

【 授权许可】

CC BY