Integrated mRNA-miRNA transcriptome analysis of bladder biopsies from patients with bladder pain syndrome identifies signaling alterations contributing to the disease pathogenesis

BMC Urology

Annette Kuhn¹  Fiona C. Burkhard²  Hubert Rehrauer³  Mustafa Besic⁴  Katia Monastyrskaya⁴  Akshay Akshay⁴  Ali Hashemi Gheinani⁵  Irene Keller⁶  Rémy Bruggmann⁶  Rosalyn M. Adam⁷ 

[1] Department of Gynaecology, Inselspital University Hospital, 3010, Bern, Switzerland;Department of Urology, Inselspital University Hospital, 3010, Bern, Switzerland;Functional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland;Functional Urology Research Group, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland;Functional Urology Research Group, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland;Urological Diseases Research Center, Boston Children’s Hospital, Boston, MA, USA;Department of Surgery, Harvard Medical School, Boston, MA, USA;Broad Institute of MIT and Harvard, Cambridge, MA, USA;Interfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland;Urological Diseases Research Center, Boston Children’s Hospital, Boston, MA, USA;Department of Surgery, Harvard Medical School, Boston, MA, USA;Broad Institute of MIT and Harvard, Cambridge, MA, USA;

关键词: Bladder;    Pain;    Cystitis;    Gene;    miRNA;    Signaling pathway;    Next-generation sequencing;   

DOI  :  10.1186/s12894-021-00934-0

来源: Springer

【 授权许可】

CC BY